Betamethasone

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Betamethasone receptor levels following betamethasone administration.

Betamethasone (BM) receptor cncentrations in the liver cytosol from adrenalectomized rats treated with 0. 2 and 2 mg BM were measured and correlated with BM concentrations in the serum and liver. The BM levels in the serum, liver cytosol and nuclei changed in a parallel fashion. One hr after BM administration, serum BM reached a peak, then decreased gradually and was undetectable at 24-48 hr. T...

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Betamethasone Abuse in Infancy

A four month old male infant born with a birth weight of 2.5 kg presented with chickenpox. On examination, he weighed 11 kg and had cushingoid features. His blood pressure was normal and had multiple papulovesicular lesions characteristic of chickenpox. The child had to be treated with oral acyclovir in view of cushingoid features. At fifteen days of life, a private practitioner had prescribed ...

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Pharmacokinetics of betamethasone after single-dose intramuscular administration of betamethasone phosphate and betamethasone acetate to healthy subjects.

BACKGROUND Betamethasone is used for its antiinflammatory and immunosuppressive effects in disorders of many organ systems. However, the pharmacokinetic properties of betamethasone in plasma after intramuscular injection of betamethasone sodium phosphate and betamethasone acetate dual-acting suspension need further investigation. OBJECTIVES The main aim of this study was to determine the phar...

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Betamethasone enemata in ulcerative colitis.

In this series a very large therapeutic dose of corticosteroid was administered by retention enemata. For the first week the author gave the equivalent of between 300 and 750 mg. of cortisone daily and for the next three weeks 150 to 375 mg. daily. The results were excellent but systemic effects were noted in all who received more than the smallest dose used.

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Kinetics of Thermal Degradation of Betamethasone Valerate and Betamethasone Dipropionate in Different Media

The effect of pH, media, phosphate concentration and ionic strength on the kinetics of thermal degradation of betamethasone valerate and betamethasone dipropionate has been investigated. A validated HPLC method has been used to determine the parent compounds and their major thermal degradation products identified in the reaction. Betamethasone-17-valerate gave rise to two major products, namely...

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ژورنال

عنوان ژورنال: Reactions Weekly

سال: 2021

ISSN: ['1179-2051', '0114-9954']

DOI: https://doi.org/10.1007/s40278-021-95757-4